Prurigo nodularis
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ReferencesPrurigo nodularis er en kronisk hudtilstand som kjennetegnes av flere faste knuter og noder, vanligvis lokalisert på de ytre delene av armer og ben. Disse lesjonene kan variere i farge fra kjøtttonet til rosa og er sterkt kløende. Tilstanden kan forekomme i alle aldersgrupper og er ofte assosiert med andre hudsykdommer som gir kronisk kløe, for eksempel atopisk dermatitt. Behandlingsalternativene omfatter kraftige antipruriginøse midler, legemidler som påvirker immunsystemet, samt medisiner som virker på nervesystemet. Håndtering av prurigo nodularis krever vanligvis langvarig behandling.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Behandlingen består vanligvis av krem eller injeksjon med steroider på det berørte området. Ved mer alvorlige eller gjenstridige tilfeller kan lysterapi eller immunsuppressive medisiner være nødvendig. Thalidomide (Thalidomid) og Lenalidomide (lenalidomid) er alternativer i alvorlige tilfeller, men de kan medføre alvorlige bivirkninger. Nyere terapier, som opioid‑reseptor‑antagonister og neurokinin‑1‑reseptor‑antagonister, viser lovende resultater ved prurigo nodularis og har færre bivirkninger enn thalidomide eller lenalidomide.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Chronic prurigo er en hudtilstand preget av langvarig kløe (som varer i over 6 uker), riperelaterte hudlesjoner og en historie med hyppige riper. Tilstanden involverer nevrobetennelse og fibrose i huden.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Prurigo nodularis er en kronisk hudlidelse preget av kløende knuter. Årsaken er ukjent, men immun‑ og nerveforstyrrelser ser ut til å bidra til kløe‑skrape‑syklusen. Per i dag er ingen behandlinger godkjent av US FDA spesielt for prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
○ Behandling – OTC‑medisiner
Å vaske lesjonsområdet med såpe hjelper ikke i det hele tatt og kan gjøre tilstanden verre. OTC‑steroidsalver kan bidra til å lindre symptomene, men de må vanligvis brukes i flere uker før bedring oppnås. Å fortsette med antihistaminer bidrar også til å dempe kløen.
#OTC steroid ointment
#OTC antihistamine
○ Behandling
#Intralesional triamcinolone injection